Do you find our website to be helpful?
Yes   No

Diabetes Drug Could Increase Risk of Bladder Cancer

Did you know that people suffering from type 2 diabetes tend to put themselves at a higher risk for bladder cancer if they take pioglitazone—a drug used to control blood sugar? According to a Canadian study, taking this anti-diabetes med may put people at double the risk.

“We believe physicians, patients, and regulatory agencies should be aware of this association when assessing the overall risks and benefits of this therapy,” lead researcher Laurent Azoulay said.

Azoulay, an assistant professor at McGill University in Montreal, added, “The association between the use of pioglitazone and bladder cancer is controversial, with several studies reporting conflicting results, from modest increased risks to no association.”

In 2011, the US Food and Drug Administration also found the link between pioglitazone and bladder cancer, requiring drug makers like Takeda Pharmaceuticals North America to include a warning on its labels regarding the risk of bladder cancer.

Pioglitazone’s sister drug, rosiglitazone, has also been tied to increased heart disease risks. Both anti-diabetes drugs are used to control blood sugar levels and are generally recommended for type 2 diabetes patients.

As the cumulative dosage of pioglitazone increases, the risk of bladder cancer also rises. Researchers revealed that for those taking the drug for at least two years, or a total of 28,000 milligrams or more, the risk of bladder cancer grew 88 percent in 137 cases out of 100,000 patients.

With these anti-diabetes drugs under fire, endocrinologist Dr. Spyros Mezitis of Lenox Hill Hospital in New York City stressed the “need to be more careful with the use of this medication.”

“If there are more studies like this, we will not be using this medication,” Dr. Mezitis added. “We have to tailor treatment to each patient, and there are other ways of controlling blood sugar.”

You Might Also Enjoy...

Tips for Preventing a UTI

Urinary tract infections (UTIs) are common but bothersome. If you’ve had a UTI, chances are good that you don’t want to get another one. The good news is that a few simple lifestyle changes can help prevent a UTI from developing.

A Look at the Different Types of Female Urinary Incontinence

Urinary incontinence is a common — but embarrassing — condition affecting millions of women. Involuntary urine leakage can keep you from enjoying life, but it doesn’t have to. Learn about common types of urinary incontinence and how to treat them.

Which Penile Prosthesis Implant is Right For Me?

Severe erectile dysfunction significantly impacts your sex life. If conservative options like medication or a penis pump haven't made a difference, don’t give up hope. A penile prosthesis implant could be a good option for you. Learn more here.

Telltale Signs You Have a Kidney Stone

Kidney stones are common, but symptoms range from sharp pain in your side to a burning sensation when you urinate. Learn more here about the telltale signs of a kidney stone and what you can do to pass the stone and stop the pain.

Does a Vasectomy Hurt?

Vasectomy is a safe, effective form of birth control. It’s a good option for men who don’t want to have children in the future, but the thought of having surgery “down there” makes many hesitate. But does a vasectomy really hurt? Find out here.

5 Tips for Preventing Kidney Stones

Kidney stones are mineral deposits that form in kidneys and pass through the urinary tract, often causing intense pain along the way. While some risk factors like family history are unavoidable, here are tips that will help you prevent stones with lifestyl