Diabetes Drug Could Increase Risk of Bladder Cancer

Did you know that people suffering from type 2 diabetes tend to put themselves at a higher risk for bladder cancer if they take pioglitazone—a drug used to control blood sugar? According to a Canadian study, taking this anti-diabetes med may put people at double the risk.

“We believe physicians, patients, and regulatory agencies should be aware of this association when assessing the overall risks and benefits of this therapy,” lead researcher Laurent Azoulay said.

Azoulay, an assistant professor at McGill University in Montreal, added, “The association between the use of pioglitazone and bladder cancer is controversial, with several studies reporting conflicting results, from modest increased risks to no association.”

In 2011, the US Food and Drug Administration also found the link between pioglitazone and bladder cancer, requiring drug makers like Takeda Pharmaceuticals North America to include a warning on its labels regarding the risk of bladder cancer.

Pioglitazone’s sister drug, rosiglitazone, has also been tied to increased heart disease risks. Both anti-diabetes drugs are used to control blood sugar levels and are generally recommended for type 2 diabetes patients.

As the cumulative dosage of pioglitazone increases, the risk of bladder cancer also rises. Researchers revealed that for those taking the drug for at least two years, or a total of 28,000 milligrams or more, the risk of bladder cancer grew 88 percent in 137 cases out of 100,000 patients.

With these anti-diabetes drugs under fire, endocrinologist Dr. Spyros Mezitis of Lenox Hill Hospital in New York City stressed the “need to be more careful with the use of this medication.”

“If there are more studies like this, we will not be using this medication,” Dr. Mezitis added. “We have to tailor treatment to each patient, and there are other ways of controlling blood sugar.”

You Might Also Enjoy...

The Benefits of Robotic Surgery

Robotic surgery harnesses precision, cutting-edge technology and puts it in the hands of highly trained surgeons. The result? Enhanced results and faster recovery for even complex urologic surgeries. Learn more about the benefits of robotic surgery.

Understanding the Different Types of Incontinence

Urinary incontinence is the involuntary leakage of urine. Whether it’s a little or a lot, it can limit your quality of lifen and you shouldn’t ignore it. Take back control and learn more about the types of incontinence here.

How a Vasectomy Works

Vasectomies are very effective in preventing pregnancy, but how does this male sterilization procedure work, exactly? Find the answers to all your questions — from what happens during surgery to when it starts being effective — right here.

Help for Your Low Testosterone

Low testosterone can affect you both physically and mentally, from loss of muscle mass to low sex drive. If you have a hormonal imbalance, it’s time to find out how testosterone replacement therapy could help you feel like yourself again.

Myths and Facts About Erectile Dysfunction

Erectile dysfunction is a common problem that makes it difficult or even impossible to achieve an erection. Men of all ages can get it, but there’s a lot of misinformation about what ED really is and how it’s treated. Learn the truth.

Tips for Preventing a UTI

Urinary tract infections (UTIs) are common but bothersome. If you’ve had a UTI, chances are good that you don’t want to get another one. The good news is that a few simple lifestyle changes can help prevent a UTI from developing.